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Your Position: > Protein > MMP-8 > MM8-M52H7

Mouse MMP-8 Protein, His Tag (active enzyme, MALS verified)

  • Synonym
    CLG1 Protein, HNC Protein, MMP-8 Protein, PMNL-CL Protein,
  • Source
    Mouse MMP-8 Protein, His Tag(MM8-M52H7) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Gly 262 (Accession # O70138-1).
    Predicted N-terminus: Phe 21
  • Molecular Characterization
    MMP-8 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 28.9 kDa. The protein migrates as 35-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 25 mM MES, 150 mM NaCl, 20% Glycerol, pH5.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
MMP-8 SDS-PAGE

Mouse MMP-8 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
MMP-8 MALS images

The purity of Mouse MMP-8 Protein, His Tag (Cat. No. MM8-M52H7) is more than 90% and the molecular weight of this protein is around 28-40 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 . The specific activity is >700 pmol/min/µg (QC tested).

  • Background
    Matrix metalloproteinase-8(MMP-8)also known as neutrophil collagenase and CLG1,is a member of matrix metalloproteinases (MMPs) family,which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.
  • Clinical and Translational Updates

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재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 525,000

가격(KRW) : 3,240,000

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약물 개발 현황

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Discontinued

Datasheet & Documentation

DMF 신청
DMF (Drug Master File)

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