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Your Position: > Intestinal-related Solutions & Services

Intestinal-related
Solutions & Services

Explore our ready-to-use intestinal organoids, cells, kits, and services. We specialize in providing ready-to-use intestinal organoids and differentiation kits, disease modeling and drug testing services. Intestinal organoids are miniaturized versions of the Intestinal that can be grown in the laboratory and used to study various aspects of intestinal biology and disease.

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Intestinal Organoids

Intestinal organoids are miniaturized versions of the Intestinal that can be grown in the laboratory and used to study various aspects of intestinal biology and disease. The successful development of an inflammatory bowel disease (IBD) model based on intestinal organoid culture could help researchers better understand the immune response of the intestinal system in IBD and other intestinal diseases.

Intestinal Organoids for Drug Screening

Drug Screening

Drug Screening

Equipped with the ability to mimic the complex environment and physiological functions of the human Intestinal, intestinal organoids provide a more accurate prediction of drug behavior in the human body.

Intestinal Organoids for Disease Modeling

Intestinal Disease Modeling

Intestinal Disease Modeling

Intestinal organoids replicate the real intestinal environment, enabling them to mimic the onset and progression of intestinal diseases more accurately.

Intestinal Organoids for Intestinal Absorption Studies

Intestinal Adsorption Studies

Intestinal Adsorption Studies

Intestinal organoids encompass all types of intestinal epithelial cells and possess physiological functions such as water, ion absorption, and transport. Functions such as intestinal absorption process of nutrients, as well as the transport and metabolism of drugs and bioactive substances can be evaluated.

Intestinal Organoids for Intestinal Development Research

Intestinal Development Research

Intestinal Development Research

The developmental process of the Intestinal is mimicked through organoids, enabling observation and research on how intestinal cells grow, differentiate, and form complex tissue structures.

Intestinal organoids and differentiation kits are available to support high-throughput differentiation of intestinal organoids from iPSCs.

The cell composition and arrangement of intestinal organoids closely resemble the structure of intestinal epithelium, enabling the maintenance of crypt characteristics even after prolonged culture
The culture cycle of intestinal organoids is relatively short, allowing for freezing and passage of the cultures.
The apical side is located on the outer layer, suitable for absorption tests.

Immunostaining of Intestinal Organoid

Immunostaining of intestinal organoid shows the marker expression of goblet cells (mucus-producing, MUC2), brush borders (Villin), enterochromaffin cells (CHGA) and endothelial cells (CD31.)

Product List

Cat. No.Description
CIPO-IWL003KReady-to-use Human iPSC-Derived Intestinal Organoids
RIPO-IWM005KHuman iPSC-Derived Intestinal Organoid Differentiation Kit
RIPO-IWM006Human iPSC-Derived Intestinal Organoid Maintenance Kit

Intestinal Cells

iPSC-differentiated intestinal cells are coming soon!

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Intestinal Services

Organoid Differentiation and Validation Services

We offer differentiation services to develop Intestinal organoids from iPSCs or human tissue. Organoids are validated by the expression of Intestinal-related protein markers to ensure differentiation and maturity.

Experiments Performed:
Intestinal differentiation
Validation by WB, IF, qPCR for MUC2, Villin and morphological evidence
Deliverables:
Custom Intestinal Organoids
Raw data and images
Detailed validation test report

Drug Screening

We can help measure the ability of intestinal epithelium to absorb nutrients as well as study inflammatory responses and drug-induced enterotoxicity.

Experiments performed:
Cell Toxicity screening test (3D)
Nutrition absorption test (3D)
Immune reaction test (ELISA)
Transepithelial/transendothelial electrical resistance measurement
Deliverables:
Detailed toxicity test report
Raw data and images

Inflammatory Bowel Disease (IBD) 

We can help to construct the IBD model and provide corresponding pathological and biochemical evidence. At the same time, we can also provide you with follow-up IBD related drug screening services.

Experiments performed:
IBD model construction on organoids
Validation by WB, IF, qPCR for pathology and immune reaction
Validation of inflammatory factors by ELISA
Deliverables:
Raw data and pictures
Detailed validation test report
Custom IBD model based on organoid

Intestinal Case Studies

Immune Response – Intestinal Organoids

Developed using our organoid differentiation kit, intestinal organoids derived from iPSCs were exposed to lipopolysaccharides to induce an immune reaction.

Immune Response of Intestinal Organoids
Study Results:
LPS induced the production of higher levels of IL-6 and CCL2, which can be dose-dependent. A significant inflammatory response was observed in the intestinal organoids.

References

1. Li, Vivian SW. "Modelling intestinal inflammation and infection using ‘mini-gut’organoids." Nature reviews Gastroenterology & hepatology 18.2 (2021): 89-90.

2. HOFFMANN P, SCHNEPEL N, LANGEHEINE M, et al. Intestinal organoid-based 2D monolayers mimic physiological and pathophysiological properties of the pig Intestinal[J]. PLoS One, 2021, 16(8): e0256143.

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