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Tau

요약

Name:Microtubule-associated protein tau
Target Synonym:MAPT,MTBT1,Paired helical filament-tau,MAPTL,Microtubule Associated Protein Tau,G Protein Beta1/Gamma2 Subunit-Interacting Factor 1,Protein Phosphatase 1, Regulatory Subunit 103,Neurofibrillary Tangle Protein,PHF-Tau,TAU,Microtubule-Associated Protein Tau, Isoform 4,Microtubule-Associated Protein Tau,PPP1R103,FTDP-17,MTBT2,DDPAC,MSTD,PPND,tau Proteins,MGC138549,FLJ31424
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:34
Lastest Research Phase:Approved

제품 리스트 구매

제품번호 제품 설명 구조 순도 특징
TAU-MY2102 Mouse Monoclonal Anti-Human p-tau217 Antibody, Mouse IgG1 (6G7C8) (MALS verified)
TAU-MY2102-sds
PT1-Y2073 Mouse Monoclonal Anti-Human Phospho-Tau (Thr181) Antibody, Mouse IgG2a (8D8C10)
PT1-Y2073-sds
PT7-Y2074 Mouse Monoclonal Anti-Human Phospho-Tau (Thr217) Antibody, Mouse IgM (6G7C8)
PT7-Y2074-sds
TAU-H5114 Human Human Tau Protein, Tag Free (MALS verified)
TAU-H5114-structure
TAU-H5114-sds
TAU-H5116 Human Human Tau-441 K18 Pre-formed Fibrils Protein, Tag Free
TAU-H5116-structure
TAU-H5116-sds
TAU-C5113 Cynomolgus Cynomolgus Tau Protein, Tag Free
TAU-C5113-structure
TAU-H5113 Human Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free
TAU-H5113-structure
TAU-H5113-sds
TAU-H5147 Human Human Tau-441 GSK-3beta-phosphorylated protein, His Tag
TAU-H5147-structure
TAU-H5147-sds
CHEK-ATP087 Human HEK293/Human Tau-K18 (GFP) Stable Cell Line
TAU-H5118 Human Human Tau-441 (K18, P301L) Protein, Tag Free (MALS verified)
TAU-H5118-structure
TAU-H5118-sds
TAU-H5117 Human Human Tau-441 / 2N4R Protein, Tag Free (MALS verified)
TAU-H5117-structure
TAU-H5117-sds
TAU-H5115 Human Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free
TAU-H5115-structure
TAU-H5115-sds
TAU-H5145 Human Human Tau-441 / 2N4R (P301S) Protein, His Tag (MALS verified)
TAU-H5145-structure
TAU-H5145-sds
TAU-H5144 Human Human Tau-441 / 2N4R (P301L) Protein, His Tag
TAU-H5144-structure
TAU-H5144-sds
TAU-H5143 Human Human Tau-410 / 2N3R Protein, His Tag (MALS verified)
TAU-H5143-structure
TAU-H5143-sds
TAU-H51H4 Human Human Tau-441 / 2N4R (241-380) Protein, His Tag (MALS verified)
TAU-H51H4-structure
TAU-H51H4-sds
TAU-H51H5 Human Human Tau-441 / 2N4R (273-380) Protein, His Tag (MALS verified)
TAU-H51H5-structure
TAU-H51H5-sds
TAU-H51H3 Human Human Tau-441 / 2N4R Protein, His Tag
TAU-H51H3-structure
TAU-H51H3-sds

일부의 생물활성 데이터

CHEK-ATP087-Cell-based assay
 Tau FACS

FACS analysis of Tau-K18 (GFP) on HEK293/Human Tau-K18 (GFP) Stable Cell Line.
HEK293/Human Tau-K18 (GFP) Stable Cell Line was red line, negative control HEK293 cells was grey line (QC tested).

TAU-C5113-ELISA
 Tau ELISA

Immobilized Cynomolgus Tau Protein, Tag Free (Cat. No. TAU-C5113) at 5 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.1-8 ng/mL (QC tested).

TAU-MY2102-MALS-HPLC
Tau MALS images

The purity of Monoclonal Anti-Human p-tau217 Antibody, Mouse IgG1 (6G7C8) (Cat. No. TAU-MY2102) is more than 90% and the molecular weight of this protein is around 130-160 kDa verified by SEC-MALS.

Synonym Name

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

Background

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Clinical and Translational Updates

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