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Your Position: > Protein > Spike protein > SPN-P52H3

Pangolin coronavirus hCoV-19/pangolin/Guangdong/1/2019 Spike Trimer Protein (R677A, KV978-979AA), His Tag

  • Synonym
    Spike,S protein,Spike glycoprotein,S glycoprotein
  • Source
    Pangolin coronavirus hCoV-19/pangolin/Guangdong/1/2019 Spike Trimer, His Tag (SPN-P52H3) is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. It contains AA Ala 10 - Pro 1205 (Accession # A0A7D6TQ96-1 (R677A, KV978-979AA)).
    Predicted N-terminus: Ala 10
  • Molecular Characterization
    Spike protein Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 137.6 kDa. The protein migrates as 170-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Spike protein SDS-PAGE

Pangolin coronavirus hCoV-19/pangolin/Guangdong/1/2019 Spike Trimer, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
 Spike protein ELISA

Immobilized Pangolin coronavirus hCoV-19/pangolin/Guangdong/1/2019 Spike Trimer, His Tag (Cat. No. SPN-P52H3) at 1 μg/mL (100 μL/well) can bind Human ACE2, Fc Tag (Cat. No. AC2-H5257) with a linear range of 0.1-8 ng/mL (Routinely tested).

  • Background
    The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • Clinical and Translational Updates

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재고상품 출발날짜: 영업일 기준 4일

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  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Approved

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