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Your Position: 홈 > Protein > Glypican 3 > GP3-HA2H9

APC-Labeled Human Glypican 3 / GPC3 Protein, His Tag (Site-specific conjugation)

INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Synonym
    GPC3,OCI5,Glypican-3,GTR2-2,MXR7,DGSX,SDYS ,SGB,SGBS,SGBS1
  • Source
    APC-Labeled Human Glypican 3, His Tag (GP3-HA2H9) is produced via conjugation of APC to Human Glypican 3, His Tag with a new generation site-specific technology under optimal conditions with a proprietary technology. Human Glypican 3, His Tag is expressed from human 293 cells (HEK293). It contains AA Gln 25 - His 559 (Accession # P51654-1).
    Predicted N-terminus: Gln 25
    Request for sequence
  • Molecular Characterization
    Glypican 3 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 64.5 kDa.

  • Conjugate

    APC

    Excitation Wavelength: 640 nm

    Emission Wavelength: 661 nm

  • Application
    Please note that this product is NOT compatible to streptavidin detection system.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Bioactivity-FACS
Glypican 3 FACS

5e5 of anti-GPC3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Glypican 3, His Tag (Cat. No. GP3-HA2H9) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

Protocol
  • Background
    Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.
  • Clinical and Translational Updates

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