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Your Position: > Protein > uPAR > UPR-M52H3

Mouse uPAR / PLAUR Protein, His Tag (SPR verified)

  • Synonym
    uPAR,PLAUR,CD87,MO3
  • Source
    Mouse uPAR, His Tag (UPR-M52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Pro 296 (Accession # P35456-1).
    Predicted N-terminus: Leu 24
  • Molecular Characterization
    Online(Leu 24 - Pro 296) P35456-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 31.7 kDa. The protein migrates as 45-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mouse uPAR, His Tag (Cat. No. UPR-M52H3) SDS-PAGE gel

Mouse uPAR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse uPAR, His Tag (Cat. No. UPR-M52H3) immobilized on CM5 Chip can bind Human PLAU, His Tag (Cat. No. PLU-H5229) with an affinity constant of 14.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 450,000

가격(KRW) : 2,970,000

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  • Latest Research Phase:Phase 2 Clinical

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