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Cytokines for Organoid Culture

Cytokines for Organoid Culture
Background
Organoids are three-dimensional tissue structures composed of a variety of cell types. Through in vitro 3D cell culture, they can continually be expanded in vitro for a long time and retain the key characteristics of organs. It can simulate the architectural and functional characteristics of human organs and even the tumor microenvironment. With recent advancements in organoid culture and the elucidation of growth factors needed to direct cell differentiation, organoids have become an indispensable tool in the process of drug development and evaluation. Currently, most organs in the human body can be formed into organoids in vitro, reproducing the cellular milleau of liver, lung, heart, blood vessels, and many others. As such, organoids have the potential to become an essential preclinical model for human disease research and drug development.

Cytokines for Organoid Culture
To support research on organoid cell culturing, ACROBiosystems has developed a series of high-quality cytokines, including EGF, Noggin, R-Spondin 1, BDNF, GDNF. These products are suitable as growth factors for organoid culture that have been verified to promote organoid growth.
Product Features

Sterile

Animal-origin Free

High Purity≥95%

High Bioactivity Verified by Organoid Models

Low Endotoxin≤0.1 EU/μg

Carrier Free

Similar to Natural Conformation and Modifications

Consistent between Batches

Data
Verified by multiple organoid culture, excellent performance and superior to competitors
The organoid culture cytokines provided by ACROBiosystems have been validated on in vitro models of gastric organoid, intestinal organoid, colonic organoid, liver ductal organoid, brain organoids and blood vessel organoids, all of which can effectively maintain organoid growth with excellent performance.

Gastric organoid

Gastric organoid

Human EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 actively support gastric organoid growth during multiple passages and long-term culture processes.

Intestinal organoid

Intestinal organoid

Human EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220) perfectly maintain intestinal organoid growth during multiple passages and long-term culture processes.

Colonic organoid

Colonic organoid

EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220), maintain colonic organoid growth well during multiple passages and long-term culture processes.

Liver ductal organoid

Liver ductal organoid

Human EGF (Cat. No. EGF-H52H3), Noggin (Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220), FGF7 (Cat. No. FG7-H52H5), FGF10 , HGF (Cat. No. HGF-H52H3) actively support liver ductal organoid growth.

Brain organoids

Brain organoids

BDNF (Cat. No. BDF-H5219), GDNF (Cat. No. GDF-H5219) support iPSC derived human brain organoids formation, expressing neuron marker TUJ1 (green) and neuron stem cell marker NESTIN (red).

Blood vessel organoids

Blood vessel organoids

VEGF110 (Cat. No. VE0-H5212) supports iPSC derived blood vessel organoids formation with net-works.

Human EGF (Cat. No. EGF-H52H3), Noggin ( Cat. No. NON-H5257), R-spondin1 (Cat. No. RS6-H4220), developed by ACROBiosystems perfectly support multiple organoids growth. The cell viability measured by ATP is better than that of competitors.
Verified by multiple organoid culture
High Bioactivity
High Bioactivity

The EGFR (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of Human EGF Protein, His Tag, premium grade ( Cat. No. EGF-H52H3). The max induction fold was approximately 56 (Routinely tested).

 High Bioactivity

Human R-Spondin 1 (21-146), His Tag, premium grade (Cat. No. RS6-H4220) induced TCF reporter activity in HEK293 cells. The EC50 for this effect is 0.0138-0.0163 µg/mL (Routinely tested).

High Bioactivity

Human FGF basic (Cat. No. BFF-H4117) stimulates proliferation of HUVEC in the range of 0-20 ng/mL. The EC50 for this effect is 0.416-0.630 ng/mL (Routinely tested).

 High Bioactivity

The bio-activity of Human Activin A (Cat. No. ACA-H421b) was determined by dose-dependent inhibition of the proliferation of MPC-11 cells. The EC50 for this effect is typically ≤ 9.5 ng/mL (Routinely tested).

High Bioactivity

Human BMP-2, Tag Free(Cat. No. BM2-H4117) induces alkaline phosphatase production in ATDC5 cells. The EC50 for this effect is 1684-1736 ng/ml (Routinely tested).

High Bioactivity

The bio-activity of Human PDGF-BB Protein (Cat. No. PDB-H4112) was determined by dose-dependent stimulation of the proliferation of mouse 3T3 cells. The ED50 was 0.5-20 ng/mL (Routinely tested).

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