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Your Position: > Activin A

Activin A

요약

Name:Activin receptor type-1
Target Synonym:ACTR-I,ACVR1,Activin A Receptor Type 1,Serine/Threonine-Protein Kinase Receptor R1,Activin A Receptor, Type I,ACVRLK2,SKR1,Activin A Receptor, Type II-Like Kinase 2,Hydroxyalkyl-Protein Kinase,Activin Receptor Type-1,EC 2.7.11.30,ACVR1A,ACTRI,EC:2.7.11.30,TSR-I,ALK2,TSRI,FOP,Activin Receptors, Type I,ALK-2,Activin receptor type I,TGF-B superfamily receptor type I,EC 2.7.11,Activin receptor-like kinase 2
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

제품 리스트 구매

일부의 생물활성 데이터

ACA-H421b-Cell-based assay
 Activin A CELL

Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) inhibits the proliferation of MPC-11 cells. The specific activity of Human Activin A Protein, Tag Free is > 5.00×10^2 IU/mg, which is calibrated against WHO Reference Reagent Activin A (Human, Recombinant) NIBSC code: 91/626 (Routinely tested).

ACA-H424x-Cell-based assay
 Activin A CELL

The bio-activity of Human Latent Activin A, His Tag (Cat. No. ACA-H424x) was determined by dose-dependent inhibition of the proliferation of MPC-11 cells. The EC50 for this effect is typically 47-66 ng/mL (Routinely tested).

ACA-H421b-SPR
 Activin A SPR

Human Activin RIIB, His Tag (Cat. No. ACB-H5226) immobilized on CM5 Chip can bind Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) with an affinity constant of 0.216 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ACA-H424x-SPR
 Activin A SPR

Biotinylated Human Activin RIIB Protein, His,Avitag (Cat. No. ACB-H82E3) immobilized on CM5 Chip can bind Human Latent Activin A, His Tag (Cat. No. ACA-H424x) with an affinity constant of 0.147 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

Activin A,INHBA

Background

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various ¦Â subunits (¦ÂA, ¦ÂB, ¦ÂC, and ¦ÂE in mammals), while Inhibins are heterodimers of a unique ¦Á subunit and one of the ¦Â subunits. Activin A is a widely expressed homodimer of two ¦ÂA chains. The ¦ÂA subunit can also heterodimerize with a ¦ÂB or ¦ÂC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human ¦ÂA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat ¦ÂA.

Clinical and Translational Updates

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