로그인 회원가입
icon_bulk_order대량 주문 Acrobiosystems for English
0
장바구니가 비어 있습니다
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > CD73

CD73

요약

Name:5-nucleotidase
Target Synonym:5 Nucleotidase (CD73),5 -nucleotidase,5 -Nucleotidase, Ecto (CD73),Ecto-5 -nucleotidase,NT5E,5 -Nucleotidase Ecto,Ecto-5-Nucleotidase,5-NT,Purine 5-Prime-Nucleotidase,5-Nucleotidase, Ecto (CD73),5 Nucleotidase (CD73),5-Nucleotidase Ecto,5-Nucleotidase,CD73 Antigen,EC 3.1.3.5,CALJA,E5NT,ENT,NT,EN,CD73,5 -NT,NT5,NTE,EC:3.1.3.5
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:29
Lastest Research Phase:Phase 3 Clinical

제품 리스트 구매

일부의 생물활성 데이터

CD3-H52H7-SPR
 CD73 SPR

Anti-CD73 antibody (Human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human CD73 Protein, His Tag (Cat. No. CD3-H52H7) with an affinity constant of 0.164 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CD3-H52H7-BLI
 CD73 BLI

Loaded Anti-CD73 MAb (Human IgG1) on AHC Biosensor, can bind Human CD73 Protein, His Tag (Cat. No. CD3-H52H7) with an affinity constant of 0.179 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

사용자 리뷰

Synonym Name

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

Background

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb) Phase 1 Clinical Neoplasms Details
BR-101 BR101; BR-101 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Solid tumours Details
BMS-986179 BMS-986179 Bristol-Myers Squibb Company Details
LY-3475070 LY-3475070 Eli Lilly And Company Details
PM-1015 PM1015; PM-1015 Phase 1 Clinical Biotheus Inc Solid tumours Details
ORIC533 ORIC-533 Phase 1 Clinical Oric Pharmaceuticals Inc Multiple Myeloma; Neoplasm Metastasis Details
IPH-5301 IPH-5301 Phase 1 Clinical Innate Pharma Solid tumours; Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Neoplasm Metastasis Details
IBI-325 IBI-325 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
Mupadolimab CPI-006 Phase 2 Clinical Corvus Coronavirus Disease 2019 (COVID-19); Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Lymphoma, Non-Hodgkin; Endometrial Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Head and Neck Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Papillomavirus Infections; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Solid tumours; Ovarian Neoplasms Details
JAB-BX102 JAB-BX102 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd Solid tumours Details
PT-199 PT-199 Phase 1 Clinical Phanes Therapeutics Inc Colonic Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Lung Neoplasms; Thyroid Neoplasms; Colorectal Neoplasms; Breast Neoplasms; Pancreatic Neoplasms; Head and Neck Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Ovarian Neoplasms; Solid tumours Details
INCA-00186 INCA-00186 Phase 1 Clinical Incyte Corp Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Gastrointestinal Neoplasms Details
CB-708 CB-708; CB708; ATG-037 Phase 1 Clinical Calithera Biosciences Inc Solid tumours; Neoplasms Details
SRF-373(Surface Oncology) SRF-373; NZV-930 Phase 1 Clinical Surface Oncology Inc Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
HLX-23 HLX-23 Phase 1 Clinical Shanghai Henlius Biologics Co Ltd Solid tumours Details
Quemliclustat AB-680 Phase 2 Clinical Arcus Biosciences Inc, Gilead Sciences Inc Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms Details
Dalutrafusp alfa AGEN-1423; GS-1423 Phase 2 Clinical Gilead Inc, Agenus Inc Solid tumours; Pancreatic Neoplasms; Neoplasms; Carcinoma, Pancreatic Ductal Details
Oleclumab MEDI-9447 Phase 3 Clinical Medimmune Llc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma; Carcinoma, Renal Cell; Hemangiosarcoma; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Liposarcoma; Prostatic Neoplasms; Osteosarcoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
Dresbuxelimab AK-119 Phase 2 Clinical Akeso Pharmaceuticals Inc Solid tumours; Idiopathic Pulmonary Fibrosis; Coronavirus Disease 2019 (COVID-19); Carcinoma, Non-Small-Cell Lung Details
Uliledlimab TJ-004309; TJD-5; TJ-4309 Phase 2 Clinical I-Mab Biopharma Co Ltd Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung Details

This web search service is supported by Google Inc.

totop