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Your Position: 홈 > Integrin alpha V beta 3

Integrin alpha V beta 3

요약

Name:Integrin alpha-V/beta-3
Target Synonym:Integrin alphaVbeta3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:22
Lastest Research Phase:Phase 3 Clinical

제품 리스트 구매

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IT3-H82W3 Mouse Biotinylated Mouse Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT3-H82W3-structure
IT3-H82W3-sds
IT3-C52W3 Cynomolgus Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free
IT3-C52W3-structure
IT3-C52W3-sds
IT3-R52E2 Rat Rat Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT3-R52E2-sds
IT3-H82W9 Human Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT3-H82W9-structure
IT3-H82W9-sds
IT3-H52E3 Human Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT3-H52E3-structure
IT3-H52E3-sds

일부의 생물활성 데이터

IT3-H52E3-SPR
Integrin alpha V beta 3 SPR

Human EDIL3, Fc Tag (Cat. No. ED3-H5259) immobilized on CM5 Chip can bind Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52E3) with an affinity constant of 38.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
IT3-R52E2-ELISA
Integrin alpha V beta 3 ELISA

Immobilized Human Vitronectin at 5 μg/mL (100 μL/well) can bind Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free (Cat. No. IT3-R52E2) with a linear range of 0.039-1.25 μg/mL (QC tested).

Protocol

Synonym Name

Integrin alpha V beta 3,ITGAV&ITGB3

Background

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
(68)Ga-RGD Phase 1 Clinical Peking Union Medical College Hospital Keloid Details
Antiangiotide HM-3; IIM-3 Phase 1 Clinical Inner Mongolia Tianqi Pharmaceutical Group Co Ltd, China Pharmaceutical University Liver Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MK-0429 MK-429; MK-0429; L-000845704 Merck Sharp & Dohme Corp Details
Pagantangentide Phase 1 Clinical Nanjing Anji Biological Technology Co Ltd, Jiangsu Aotexin Biomedical Technology Co Ltd, China Pharmaceutical University Arthritis, Rheumatoid; Rheumatic Diseases Details
IDL-2965 IDL-2965 Phase 2 Clinical Indalo Therapeutics Inc Non-alcoholic Fatty Liver Disease; Idiopathic Pulmonary Fibrosis Details
ProAgio Phase 1 Clinical National Cancer Institute Solid tumours; Pancreatic Neoplasms Details
68Ga-NOTA-3PTATE-RGD 68Ga-NOTA-3PTATE-RGD; 68Ga-NOTA-3P-TATE-RGD Phase 1 Clinical Peking Union Medical College Hospital Neuroendocrine Tumors; Lung Neoplasms Details
99mTc-3PRGD2 99mTc-3PRGD2 Phase 3 Clinical Peking University Lymphatic Metastasis; Lung Neoplasms Details
68Ga-NOTA-BBN-RGD 68Ga-NOTA-BBN-RGD Phase 1 Clinical Peking Union Medical College Hospital Breast Neoplasms; Prostatic Neoplasms Details
Alfatide[18F] 18F-AlF-NOTA-PRGD2; 18F-alfatide; alfatide II; AlF-NOTA-PRGD2-[18F] Phase 3 Clinical Jiangsu Smk Pharmaceutical Co Ltd, Taizhou Kairui Pharmaceutical Technology Co Ltd Carcinoma, Bronchogenic; Head and Neck Neoplasms; Neoplasms; Soft Tissue Neoplasms; Contrast agents; Breast Neoplasms; Lymphoma Details
BGC-0222 BGC0222; BGC-0222 Phase 1 Clinical Gaorui Yaoye (Beijing) Technologies Co Ltd, Brightgene Bio-Medical Technology Co Ltd Solid tumours Details
Ga-68 NODAGA-RGD [68Ga]Theranost; Theranost 68Ga-RGD Phase 1 Clinical Advanced Imaging Projects, Zentralklinik Bad Berka, National Cancer Institute Neovascularization, Pathologic; Prostatic Neoplasms; Contrast agents; Breast Neoplasms; Brain Neoplasms; Lung Neoplasms Details
fb-PMT NP-100; NP-751 Phase 1 Clinical NanoPharmaceuticals LLC Glioma Details
OTT-166 OTT-166 Phase 2 Clinical OcuTerra Therapeutics Inc Diabetic Retinopathy Details
[68Ga]-FF58 Phase 1 Clinical Novartis Pharma Ag Stomach Neoplasms; Esophageal Neoplasms; Glioblastoma; Brain Neoplasms; Carcinoma, Pancreatic Ductal Details

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