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TNF-alpha

요약

Name:Tumor necrosis factor α
Target Synonym:ICD1,Tumor necrosis factor,Tumor Necrosis Factor (TNF Superfamily, Member 2),Tumor Necrosis Factor Ligand 1F,Tumor Necrosis Factor-Alpha,TNF Superfamily, Member 2,TNF, Macrophage-Derived,TNF, Monocyte-Derived,APC1 Protein,TNLG1F,DIF,NTF,TNF-a,TNF-alpha,ICD2,N-terminal fragment,TNF,Tumor necrosis factor ligand superfamily member 2,Cachectin,TNFSF2,TNFA
Number of Launched Drugs:61
Number of Drugs in Clinical Trials:63
Lastest Research Phase:Approved

제품 리스트 구매

제품번호 제품 설명 구조 순도 특징
TNA-H82F3 Human Biotinylated Human TNF-alpha Protein, Fc,Avitag™ (MALS verified)
TNA-H82F3-structure
TNA-H82F3-sds
RAS-SP003 Human Human TNF-alpha ELISPOT Kit
RAS-SP004 Mouse Mouse TNF-alpha ELISPOT Kit
RES-A027 Human resDetect™ Human Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit (Residue Testing)
EP-165 Human TNF-alpha : TNFR1[HRP] Inhibitor Screening ELISA Kit-Pre coated plate
GMP-TNAH23 Human GMP Human TNF-alpha Protein
GMP-TNAH23-structure
GMP-TNAH23-sds
GMP-TNAH23-hplc
TNA-M5257 Mouse Mouse TNF-alpha Protein, Fc Tag, active trimer (MALS verified)
TNA-M5257-structure
TNA-M5257-sds
EP-161 Human TNF-alpha : TNFR2 [Biotinylated] Inhibitor Screening ELISA Kit
TNA-H5255 Human Human TNF-alpha Protein, Fc Tag (MALS verified)
TNA-H5255-structure
TNA-H5255-sds
EP-147 Human TNF-alpha [Biotinylated] : TNFR2 Inhibitor Screening ELISA Kit
CRS-D002 Human Human Tumor Necrosis Factor Alpha (TNF-α) ELISA Assay Pair
TNA-M52H3 Mouse Mouse TNF-alpha Protein, His Tag
TNA-M52H3-structure
TNA-M52H3-sds
EP-143 Human TNF-alpha [Biotinylated] : TNFR1 Inhibitor Screening ELISA Kit
TNA-BLM494 Mouse Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5) (MALS verified)
TNA-BLM494-sds
TNA-AM493 Mouse Monoclonal Anti-TNF-alpha Antibody, Human IgG1 (13B8) (MALS verified)
TNA-AM493-sds
TNA-AM494 Mouse Monoclonal Anti-TNF-alpha Antibody, Human IgG1 (16H5) (MALS verified)
TNA-AM494-sds
TNA-Y59 Mouse Monoclonal Anti-TNF-alpha Antibody, Mouse IgG1 (16H5)
TNA-Y58 Mouse Monoclonal Anti-TNF-alpha Antibody, Mouse IgG1 (13B8)
CRS-A002 Human ClinMax™ Human Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit
TNA-C52H3 Canine Canine TNF-alpha Protein, His Tag, active trimer (MALS verified)
TNA-C52H3-structure
TNA-C52H3-sds
TNA-H5228 Human Human TNF-alpha Protein, His Tag, active trimer (MALS verified)
TNA-H5228-structure
TNA-H5228-sds
TNA-M82E9 Mouse Biotinylated Mouse TNF-alpha Protein, His,Avitag™, active trimer (MALS verified)
TNA-M82E9-structure
TNA-M82E9-sds
TNA-H82E3 Human Biotinylated Human TNF-alpha Protein, His,Avitag™, active trimer (MALS verified)
TNA-H82E3-structure
TNA-H82E3-sds
TNA-H8211 Human Biotinylated Human TNF-alpha Protein, epitope tag free, ultra sensitivity (primary amine labeling), active trimer (MALS verified)
TNA-H8211-structure
TNA-H8211-sds
TNA-H4211 Human Human TNF-alpha Protein, premium grade
TNA-H4211-structure
TNA-H4211-sds

일부의 생물활성 데이터

GMP-TNAH23-Cell-based assay
 TNF-alpha CELL

GMP Human TNF-alpha Protein (Cat. No. GMP-TNAH23) induces cytotoxicity effect on the WEHI-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The specific activity GMP Human TNF-alpha Protein (Cat. No. GMP-TNAH23) is ≥ 2.00×10^7 IU/mg, which is calibrated against human TNF-alpha WHO International Standard (NIBSC code: 12/154) (QC tested).

TNA-H5228-Cell-based assay
 TNF-alpha CELL

Human TNF-alpha Protein, His Tag (Cat. No. TNA-H5228) induces cytotoxicity effect on the WEH1-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The EC50 for this effect is 0.013-0.074 ng/mL (Routinely tested).

TNA-BLM494-SPR
 TNF-alpha SPR

Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5) (Cat. No. TNA-BLM494) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 75.9 pM as determined in a SPR assay (Biacore 8K) (Routinely  tested).

TNA-AM493-SPR
 TNF-alpha SPR

Monoclonal Anti-TNF-alpha antibody, Human IgG1 (13B8) (Cat. No. TNA-AM493) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 0.133 nM as determined in a SPR assay (Biacore 8K) (Routly tested).

Synonym Name

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα

Background

Tumor necrosis factor alpha (TNFα)  is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) Approved Hisun-Pfizer AnBaiNuo Mainland China Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis Wyeth Europa Ltd 2010-02-26 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic Details
Infliximab biosimilar (Bionovis/The Instituto Vital Brazil) Approved Bionovis, The Instituto Vital Brazil Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease Details
Etanercept biosimilar (Intas Biopharmaceuticals) Approved Intas Biopharmaceuticals Intacept India Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis Intas Biopharmaceuticals 2015-03-01 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic Details
Anti-tumour necrosis factor-alpha antibody Approved Materia Medica Holding Research And Production Company Artrofoon, Arthrofoon Arthritis, Rheumatoid; Osteoarthritis Details
Etanercept biosimilar (AryoGen Biopharma) Approved Aryogen Biopharma Altebrel Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic Details
Etanercept biosimilar (Nanogen Biopharmaceutical) Approved Nanogen Biopharmaceutical Co Nanercept Vietnam Psoriasis; Arthritis, Rheumatoid Nanogen Biopharmaceutical Co 2019-01-01 Arthritis, Rheumatoid; Psoriasis Details
Etanercept biosimilar (PROBIOMED) Approved Probiomed Infinitam Mexico Arthritis, Rheumatoid Probiomed 2014-01-01 Arthritis, Rheumatoid Details
Adalimumab biosimilar (Reliance Life Sciences) R-TPR-021 Approved Reliance Life Sciences Adfrar IB India Colitis, Ulcerative; Psoriasis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Psoriatic Reliance Life Sciences, Torrent Pharma 2016-01-12 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic Details
Infliximab biosimilar (AXXO) Approved Axxo Russian Federation Crohn Disease; Autoimmune Diseases Axxo 2013-01-01 Autoimmune Diseases; Crohn Disease Details
Etanercept biosimilar (Mochida) LBEC-0101 Approved Mochida Pharmaceutical Co Ltd Japan Arthritis, Juvenile; Arthritis, Rheumatoid null 2018-01-19 Arthritis, Rheumatoid; Arthritis, Juvenile Details
Etanercept biosimilar (Amega Biotech) Approved Amega Biotech Enerceptan Argentina Arthritis, Rheumatoid Amega Biotech 2012-01-01 Arthritis, Rheumatoid Details
Etanercept biosimilar (Mylan) YLB-113 Approved Rubin Ltd, Mylan Nv Nepexto EU Arthritis, Rheumatoid; Spondylarthropathies; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Plaque psoriasis Mylan Ire Healthcare Ltd 2020-05-20 Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic; Plaque psoriasis Details
Recombinant human type II tumor necrosis factor receptor-antibody fusion protein(Shanghai Cp Guojian) Approved Shanghai Cp Guojian Pharmaceutical Co Ltd 益赛普 Spondylitis, Ankylosing; Arthritis, Rheumatoid Details
Adalimumab biosimilar (CTTQ Pharma) Approved Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Mainland China Spondylitis, Ankylosing; Arthritis, Rheumatoid Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2022-01-18 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease Details
Adalimumab biosimilar (Zydus Cadila) ZRC-3197 Approved Zydus Cadila Exemptia, Adaly India Arthritis, Juvenile; Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing Zydus Cadila 2014-12-09 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic Details
Adalimumab biosimilar (Hisun Pharma) HS-016 Approved Zhejiang Hisun Pharmaceutical Co Ltd 安健宁 Mainland China Spondylitis, Ankylosing; Arthritis, Rheumatoid Hisun Biopharmaceutical Co Ltd 2019-12-06 Spondylitis, Ankylosing; Arthritis, Rheumatoid Details
Infliximab biosimilar (Hisun Pharma) HS-626 Approved Zhejiang Hisun Pharmaceutical Co Ltd Mainland China Psoriasis Hisun Biopharmaceutical Co Ltd 2021-09-24 Psoriasis Details
Adalimumab biosimilar (Coherus BioSciences) CHS-1420 Approved Coherus Biosciences Inc Yusimry United States Colitis, Ulcerative; Plaque psoriasis; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Crohn Disease Coherus Biosciences Inc 2021-12-17 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis; Crohn Disease Details
PG-201 PG-201 Approved Viromed Layla South Korea Osteoarthritis Pmg Pharm Co Ltd 2012-01-01 Osteoarthritis Details
Adalimumab biosimilar (Biocad) BCD-057 Approved Biocad Russian Federation Psoriasis Biocad 2019-03-01 Psoriasis Details
Adalimumab biosimilar (Bio-Thera Solutions) BAT-1406 Approved Bio-Thera Solutions Ltd 格乐立 Mainland China Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Uveitis Bio-Thera Solutions Ltd 2019-11-04 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Uveitis; Crohn Disease Details
Adalimumab biosimilar (Innovent Biologics) IBI-303 Approved Innovent Biologics(Suzhou) Co Ltd 苏立信 Mainland China Crohn Disease; Pediatric Crohn's disease Innovent Biologics(Suzhou) Co Ltd 2020-09-02 Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Uveitis; Plaque psoriasis; Crohn Disease Details
Luminol sodium MP-1032 Approved Selvim, Metrio Psoriasis; Immune System Diseases null 1997-01-01 Immune System Diseases; Psoriasis Details
Adalimumab biosimilar (Boehringer Ingelheim) BI-695501 Approved C.H. Boehringer Sohn Ag & Co. Kg Cyltezo United States Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis Boehringer Ingelheim Gmbh 2017-08-25 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease Details
Infliximab biosimilar (Amgen) ABP-710 Approved Amgen Inc Avsola United States Plaque psoriasis; Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease Amgen Inc 2019-12-06 Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Plaque psoriasis; Crohn Disease Details
Etanercept biosimial (Sandoz) GP-2015 Approved Clariant Produkte (Schweiz) Ag Erelzi EU Arthritis, Juvenile; Plaque psoriasis; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Rheumatoid Sandoz Gmbh 2016-08-30 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis Details
Adalimumab biosimilar (Amgen) ABP-501 Approved Amgen Inc Amgevita, Amjevita, Solymbic EU Amgen Europe Bv 2016-09-23 Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease; Plaque psoriasis Details
Infliximab Biosimilar (Genor Biopharma) GB-242 Approved Genor Biopharma Co Ltd 佳佑健 Mainland China Spondylitis, Ankylosing; Crohn Disease; Psoriasis; Colitis, Ulcerative; Arthritis, Rheumatoid Yuxi Genor Biotechnology Co Ltd 2022-02-23 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease Details
Etanercept biosimilar (Hanwha Chemical) HD-203; MK-8953 Approved Hanwha Chemical Davictrel Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic Details
Infliximab biosimilar (Nichiiko/Aprogen) NI-071; GS-071; GS-07; AP-07 Approved Nichi-Iko Pharmaceutical Co Ltd, Aprogen Japan Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis Nichi-Iko Pharmaceutical Co Ltd 2017-09-27 Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease Details
Opinercept E-11; ENIA-11 Approved Tsh Biopharm, Mycenax Biotech Inc TuNEX Taiwan Arthritis, Rheumatoid null 2017-01-01 Spondylitis, Ankylosing; Arthritis, Rheumatoid Details
Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan) FKB-327 Approved Fujifilm Kyowa Kirin Biologics Co Ltd Hulio EU Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic Viatris Ltd 2018-09-16 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease Details
Adalimumab biosimilar (Mylan/Biocon) BMO-2; MYL-1401-A Approved Biocon Ltd United States Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Mylan Pharmaceuticals Inc 2020-07-06 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Details
Adalimumab biosimilar (Celltrion) CT-P17 Approved Celltrion Inc Yuflyma EU Arthritis, Rheumatoid; Colitis, Ulcerative; Hidradenitis Suppurativa; Psoriasis; Spondylitis, Ankylosing; Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Juvenile; Plaque psoriasis; Crohn Disease; Uveitis; Arthritis, Psoriatic Celltrion Healthcare Hungary Kft 2021-02-11 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis; Crohn Disease Details
Infliximab TA-650 Approved Janssen Global Services Llc Remicade, 类克, Avakine, CenTNF EU Psoriasis Janssen Biologics Bv 1998-08-24 Parapsoriasis; Diabetic macular oedema; Psoriasis; Pediatric ulcerative colitis; Vitreoretinopathy, Proliferative; Glaucoma; Arthritis, Psoriatic; Colitis, Ulcerative; Aneurysm; Retinal Detachment; Visual Acuity; Uveitis; Hidradenitis Suppurativa; Granulomatous Disease, Chronic; Pulmonary Disease, Chronic Obstructive; Crohn Disease; Stevens-Johnson Syndrome; Behcet Syndrome; Diabetic Retinopathy; Melanoma; Spondylarthropathies; Inflammatory Bowel Diseases; Pancreatitis; Scleritis; Giant Cell Arteritis; Dermatomyositis; Pediatric Crohn's disease; Vasculitis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Polymyositis; Graft vs Host Disease; Bipolar Disorder; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mucocutaneous Lymph Node Syndrome; Stroke; Polymyalgia Rheumatica; Arthritis, Juvenile Details
Edaravone/(+)-2-Decanol SIM-071201; Y-2 Approved Jiangsu Simcere Pharmaceutical Co Ltd Mainland China Stroke Nanjing Simcere Dongyuan Pharmaceutical Co Ltd 2020-07-29 Brain Infarction; Intracranial Hemorrhages; Cerebral Hemorrhage; Stroke; Alzheimer Disease; Amyotrophic Lateral Sclerosis Details
Adalimumab biosimilar (Pfizer) PF-06410293 Approved Pfizer Pharmaceuticals Ltd (China) Amsparity, Abrilada, Fyzoclad EU Arthritis, Psoriatic; Hidradenitis Suppurativa; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Uveitis; Psoriasis Pfizer Europe Ma Eeig 2019-11-15 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease Details
Pomalidomide IMID-4047; CDC-394; CC-4047; IMiD-1 Approved Celgene Corp Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 Mainland China Multiple Myeloma Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2013-02-08 Pulmonary Fibrosis; Anemia, Sickle Cell; Atypical Squamous Cells of the Cervix; Neurofibromatosis 1; Sarcoma, Kaposi; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Glioma; Waldenstrom Macroglobulinemia; Primary Myelofibrosis; Sarcoma; Prostatic Neoplasms; Thrombocytosis; Lung Diseases, Interstitial; Solid tumours; Central Nervous System Neoplasms; Multiple Myeloma; Hodgkin Disease; Scleroderma, Systemic; Pancreatic Neoplasms; Kidney Diseases; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Myeloproliferative Disorders; Plasmacytoma; Polycythemia Vera; Medulloblastoma; Bone Marrow Neoplasms Details
Adalimumab biosimilar (LG Life Sciences) LBAL Approved Lg Chemical Ltd, Mochida Pharmaceutical Co Ltd Japan Behcet Syndrome; Uveitis, Intermediate; Uveitis, Posterior; Panuveitis; Crohn Disease; Colitis, Ulcerative; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis, Juvenile Mochida Pharmaceutical Co Ltd 2021-03-23 Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis, Posterior; Behcet Syndrome; Panuveitis; Crohn Disease Details
Lenalidomide CC-5013; IMiD-3; ENMD-0997; STAR-LLD; CDC-501; IMID-5013; CDC-5013 Approved Celgene Corp Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo EU Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular Celgene Europe Bv 2005-12-27 Leukemia; Leukemia, Myeloid; Immunoproliferative Small Intestinal Disease; Leukemia, Erythroblastic, Acute; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Ovarian Neoplasms; Medulloblastoma; Intestinal Neoplasms; Bone Marrow Neoplasms; Solid tumours; Kidney Neoplasms; Liver Neoplasms; HIV Infections; Hematologic Diseases; Optic Nerve Glioma; Leukemia, Promyelocytic, Acute; Ependymoma; Anemia, Refractory, with Excess of Blasts; Plaque, Amyloid; Leukemia, Hairy Cell; Anemia; Paraproteinemias; Pain; Polycythemia Vera; Rhabdoid Tumor; Hodgkin Disease; Myelodysplastic Syndromes; Nerve Degeneration; Lymphomatoid Granulomatosis; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Anemia, Refractory; Leukemia-Lymphoma, Adult T-Cell; Plasmacytoma; Lymphoma, Large B-Cell, Diffuse; Blood Protein Disorders; Neoplasms; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Hypothalamic Neoplasms; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Acute; Urinary Bladder Neoplasms; Multi Details
Certolizumab pegol PHA-738144; CDP-870; CZP Approved Ucb Cimzia, Cimziat Mainland China Arthritis, Rheumatoid Ucb Pharma Sa 2008-04-22 Infertility, Male; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Spondylarthropathies; Spondylarthritis; Psoriasis; Cystitis, Interstitial; Colitis, Ulcerative; Arthritis, Psoriatic; Osteoarthritis, Spine; Crohn Disease; Plaque psoriasis Details
Adalimumab biosimilar (Jiangsu Zhonghe/Shanghai Junshi/Jiangsu T-Mab) UBP-1211; 9MW0113; 9-MW-0113; 9-MW0113; 9MW-0113 Approved Shanghai Junshi Biosciences Co Ltd, Jiangsu Zhonghe Pharmaceutical Technology Co Ltd, Jiangsu T-Mab Bio-Pharmaceuticals Co Ltd, Mabwell (Shanghai) Bioscience Co Ltd 君迈康 Mainland China Crohn Disease; Pediatric Crohn's disease; Uveitis; Arthritis, Juvenile Shanghai Junshi Biosciences Co Ltd 2022-03-01 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Uveitis; Crohn Disease Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Osteosarcoma; Leprosy, Lepromatous; Drug Resistant Epilepsy; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Waldenstrom Macroglobulinemia; Cholangitis, Sclerosing; HIV Wasting Syndrome; Arachnoiditis; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Pancreatitis, Chronic; Lymphoma, Follicular; Sarcoma; Xerostomia; Burning Mouth Syndrome; Neoplasm Metastasis; Mycobacterium avium-intracellulare Infection; Vascular Malformations; Amyotrophic Lateral Sclerosis; Melanoma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Erythema Nodosum; Anemia, Sideroblastic; Uterine Neoplasms; Lymphoma, Non-Hodgkin; Glioma; Angiodysplasia; Pelvic Pain; Appendiceal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Mycobacterium Infections; Gastric Antral Vascular Ectasia; Carcinoid Tumor; Lupus Erythematosus, Discoid; Stomatitis, Aphthous; Rhabdomyosarcoma; Details
Golimumab CNTO-148; rTNV148B Approved Janssen Global Services Llc Simponi, Simponi aria, Simponi/Simponi aria Mainland China Arthritis, Rheumatoid; Spondylitis, Ankylosing Janssen Biologics Bv 2009-04-24 Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Arthritis, Psoriatic; Asthma; Crohn Disease; Labyrinth Diseases Details
Etanercept biosimilar (Samsung Bioepis) SB-4 Approved Samsung Bioepis Co Ltd Eticovo, Benepali United States Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing; Arthritis, Psoriatic Samsung Bioepis Co Ltd 2016-01-13 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic Details
Etanercept TNR-001 Approved Pfizer Pharmaceuticals Ltd (China), Amgen Inc 恩利, Enbrel, Lifmior Mainland China Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid C.H. Boehringer Sohn Ag & Co. Kg 1998-11-02 Cachexia; Psoriasis; Myositis, Inclusion Body; Prostatic Neoplasms; Asthma; Alzheimer Disease; Arthritis, Psoriatic; Lichen Planus; Bone Neoplasms; Inflammation; Uveitis; Respiratory Distress Syndrome, Adult; Arthritis; Obesity; Hidradenitis Suppurativa; Lung Neoplasms; Stomatitis; Plaque psoriasis; Neoplasm Metastasis; Acute Lung Injury; Kidney Failure, Chronic; Vitiligo; Lupus Erythematosus, Cutaneous; Diabetes Mellitus, Type 1; HIV Infections; Tinnitus; Solid tumours; Bronchiolitis Obliterans; Leukemia; Lupus Erythematosus, Discoid; Arthritis, Rheumatoid; Metabolic Syndrome; Vasculitis; Granulomatosis with Polyangiitis; Spondylarthritis; Spondylitis, Ankylosing; Synovitis; Sjogren's Syndrome; Chronic Urticaria; Anorexia; Fanconi Anemia; Graft vs Host Disease; Arthritis, Juvenile; Pulmonary Fibrosis Details
Adalimumab ABT-D2E7; LU-200134; D2E7 Approved Abbvie Inc Humira, Trudexa, 修美乐 EU Colitis, Ulcerative; Uveitis; Psoriasis; Hidradenitis Suppurativa Stada Arzneimittel Ag 2002-12-31 Uveitis, Posterior; Colitis, Ulcerative; Cystitis, Interstitial; Arthritis, Psoriatic; Osteoarthritis, Knee; Asthma; Hidradenitis Suppurativa; Uveitis; Arthritis; Glomerulosclerosis, Focal Segmental; Mucopolysaccharidosis II; Nephrotic Syndrome; Osteoarthritis; Crohn Disease; Plaque psoriasis; Diabetic Retinopathy; Choroidal Neovascularization; Panuveitis; Pouchitis; Pyoderma Gangrenosum; Pain; Uveitis, Intermediate; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylarthritis; Sarcoidosis; Bursitis; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Mucopolysaccharidosis I; Nephrosis, Lipoid; Dupuytren Contracture; Psoriasis; Mucopolysaccharidosis VI Details
Infliximab biosimilar (Merck & Co/Samsung Bioepis) SB-2 Approved Samsung Bioepis Co Ltd, Merck & Co Inc Renflexis, Flixabi United States Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid Samsung Bioepis Co Ltd 2016-05-26 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease Details
Ozoralizumab PF-5230896; PF-05230896; TS-152; ATN-103 Approved Ablynx Nv Japan Arthritis, Rheumatoid Taisho Pharmaceutical Co Ltd 2022-09-26 Arthritis, Rheumatoid Details
Infliximab biosimilar (Celltrion) CT-P13 Approved Celltrion Inc Remsima, Inflectra, Inflectra/Remsima, Flammegis Japan Arthritis, Psoriatic; Arthritis, Rheumatoid; Crohn Disease; Psoriasis; Colitis, Ulcerative Celltrion Inc 2013-09-10 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Urologic Neoplasms; Crohn Disease Details
Adalimumab biosimilar (Sandoz) GP-2017 Approved Sandoz Hefiya, Hyrimoz, Halimatoz United States Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Sandoz Inc 2018-07-26 Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Plaque psoriasis; Crohn Disease Details
Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical) 301S Approved Shanghai Cp Guojian Pharmaceutical Co Ltd, Cipla Gmbh Yisaipu, Etacept, 益赛普, Etanar Mainland China Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis Shanghai Cp Guojian Pharmaceutical Co Ltd 2005-06-20 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis Details
Adalimumab biosimilar (Samsung Bioepis) SB-5 Approved Samsung Bioepis Co Ltd Imraldi, Hadlima United States Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis Samsung Bioepis Co Ltd 2017-08-24 Pediatric Crohn's disease; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Plaque psoriasis; Crohn Disease Details
Infliximab biosimilar (Shanghai Biomabs) CMAB-008; STI-002 Approved Shanghai Biomabs Pharmaceuticals Co Ltd 百类停, 类停 Mainland China Pediatric Crohn's disease; Crohn Disease; Spondylitis, Ankylosing; Colitis, Ulcerative; Psoriasis; Arthritis, Rheumatoid Taizhou Mabtech Pharmaceutical Co Ltd 2021-07-12 Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease Details
Adalimumab biosimilar (Shanghai Henlius Biotech) HLX-03 Approved Shanghai Henlius Biotech Co Ltd 汉达远 Mainland China Uveitis, Intermediate; Uveitis, Posterior; Panuveitis Shanghai Henlius Biotech Co Ltd 2020-12-02 Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Immune System Diseases; Psoriasis; Uveitis, Posterior; Plaque psoriasis; Panuveitis Details
Infliximab biosimilar (Pfizer) PF-6438179; GP-1111; PF-06438179 Approved Pfizer Inc Ixifi, Zessly Japan Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Rheumatoid; Arthritis, Psoriatic Pfizer Inc 2013-09-09 Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric ulcerative colitis; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease Details
Infliximab biosimilar (Reliance Life Sciences) BOW-015; R-TPR-015 Approved Epirus Biopharmaceuticals Inc Infimab Arthritis, Rheumatoid Details
Adalimumab biosimilar (Fresenius Kabi) MSB-11022 Approved Merck Serono, Fresenius Kabi Ag Idacio, Kromeya EU Colitis, Ulcerative; Psoriasis; Hidradenitis Suppurativa Fresenius Kabi Deutschland Gmbh 2019-04-02 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Adalimumab biosimilar (CinnaGen) Phase 3 Clinical Cinnagen Arthritis, Rheumatoid Details
Recombinant human anti-TNFα monoclonal antibody (Huaota Biopharma) Phase 3 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Spondylitis, Ankylosing; Psoriasis; Arthritis; Plaque psoriasis Details
Adalimumab biosimilar (AXXO) Clinical Axxo Arthritis, Rheumatoid; Arthritis, Psoriatic Details
IBPM005IX (Inbiopro Solutions) Clinical Inbiopro Solutions Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Arthritis, Psoriatic; Crohn Disease Details
Etanercept (Neurokine Pharmaceuticals) NP-1; NK-001 Clinical Pivot Pharmaceuticals Cognition Disorders Details
Anti-tumour necrosis factor alpha (Livzon) Phase 1 Clinical Livzon Pharmaceutical Group Inc Autoimmune Diseases Details
Adalimumab biosimilar (Danhong Pharma) BC-002 Phase 3 Clinical Shandong Danhong Pharmaceutical Co Ltd Spondylitis, Ankylosing; Arthritis, Rheumatoid Details
Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical) Phase 3 Clinical Tonghua Dongbao Pharmaceutical Co Ltd Arthritis, Rheumatoid; Plaque psoriasis Details
Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products) Phase 3 Clinical Wuhan Institute Of Biological Products Co Ltd Plaque psoriasis Details
JNJ-63823539 JNJ-63823539 Phase 1 Clinical Janssen Global Services Llc Arthritis, Rheumatoid Details
SAR-442970 SAR-442970 Phase 1 Clinical Sanofi Inflammation Details
Adalimumab biosimilar (Weimingdamu Biotech) Phase 1 Clinical Anhui Weiming Damu Biomedicine Co Ltd Arthritis, Rheumatoid Details
Adalimumab biosimilar(BioXpress) BX-2922; BXT-2922 Clinical Bioxpress Therapeutics Sa Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Rheumatoid; Arthritis, Juvenile; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease Details
Adalimumab biosimillar(Huabo) Onco-3010; HOT-3010 Phase 3 Clinical Huabo Biopharm Co Ltd Arthritis, Rheumatoid Details
Infliximab biosimilar (Ospedale San Raffaele) Phase 1 Clinical Ospedale San Raffaele Takayasu Arteritis Details
Recombinant anti-TNFα monoclonal antibody (Livzon Group) AT-132; LZM-001 Phase 2 Clinical Livzon Pharmaceutical Group Inc Arthritis, Rheumatoid Details
Wogonin Phase 1 Clinical Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University Respiratory Tract Infections; Neoplasms Details
HMPL-004 (Hutchison Medipharma) HMPL-004 Details
Infliximab biosimilar (Biocad) BCD-055 Biocad Details
Tumour necrosis factor alpha kinoid TNF-K; TNF-K005 Neovacs Details
ME-3183 ME-3183 Phase 1 Clinical Meiji Seika Pharma Co Ltd Psoriasis Details
JNJ-61178104 JNJ-61178104 Phase 1 Clinical Janssen Global Services Llc Autoimmune Diseases Details
Etanercept biosimilar (Coherus Biosciences) CHS-0214; BAX-2200 Coherus Biosciences Inc Details
Doramapimod BIRB-796-BS; BIRB-0796; BIRB-796; BIBR-796 C.H. Boehringer Sohn Ag & Co. Kg Details
LY-3114062 LY3114062; LY-3114062 Eli Lilly And Company Details
Tanfanercept HBM-9036; HL-036 Phase 3 Clinical Hanall Dry Eye Syndromes; Xerophthalmia Details
Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical) Phase 1 Clinical Qilu Pharmaceutical Co Ltd Arthritis, Rheumatoid; Spondylitis, Ankylosing Details
Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine) Phase 1 Clinical Shanghai Harmony Pharmaceutical Technology Co Ltd Details
Adalimumab biosimilar (DZM Biotech) Phase 1 Clinical Dzm Biotech Ltd Arthritis, Rheumatoid Details
Etanercept biosimilar (Suzhou Genemen Biotech) BF-02; GM-02 Phase 1 Clinical Suzhou Genemen Biotech Co Ltd Spondylitis, Ankylosing Details
Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical) Phase 1 Clinical North China Pharmaceutical Company Ltd Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis Details
Adalimumab biosimilar (Hetero Drugs) Phase 3 Clinical Hetero Drugs Ltd Arthritis, Rheumatoid Details
Adalimumab biosimilar (Prestige BioPharma) PBP-1502 Phase 1 Clinical Prestige BioPharma Ltd Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Coronavirus Disease 2019 (COVID-19); Healthy Aging; Inflammation Details
CC-11050 CC-11050 Phase 2 Clinical Celgene Corp HIV Infections; Lupus Erythematosus, Cutaneous; Tuberculosis Details
Etanercept biosimilar (Clover Biopharmaceuticals) SCB-808 Phase 3 Clinical Sichuan Sanyecao Bio-Pharmaceutical Co Ltd Spondylitis, Ankylosing; Arthritis, Rheumatoid; Thrombocytopenia Details
Adalimumab biosimilar (Hualan Biological Engineering) Phase 3 Clinical Hualan Genetic Engineering Co Ltd Spondylitis, Ankylosing; Psoriasis; Arthritis Details
Hemay007 Hemay-007 Phase 2 Clinical Tianjin Hemay Bio-Tech Co Ltd Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative Details
Golimumab biosimilar (Bio-thera) BAT-2506 Phase 3 Clinical Bio-Thera Solutions Ltd Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis Details
Monoclonal Antibody (Mab) sB24M Phase 1 Clinical Swiss Biopharma Med GmbH Pyoderma Gangrenosum; Pyoderma Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Leukemia; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Solid tumours; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
Certolizumab (Intrexon) AG-014 Phase 1 Clinical Intrexon Corporation Inflammatory Bowel Diseases Details
PM-1016 PM1016; TILT-123 Phase 2 Clinical Tilt Biotherapeutics Ltd Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma Details
CC-10015 CC-10015 Phase 2 Clinical Celgene Corp Sarcoidosis; Multiple Myeloma; Lupus Erythematosus, Systemic Details
Hemay-005 Hemay-005 Phase 3 Clinical Hainan Hailing Chemipharma Corporation Ltd, Tianjin Hemay Pharmaceutical Co Ltd Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Pulmonary Disease, Chronic Obstructive; Behcet Syndrome; Plaque psoriasis; Dermatitis, Atopic Details
Adalimumab biosimilar(Incepta) Phase 3 Clinical Incepta Pharmaceuticals Ltd Arthritis, Rheumatoid Details
IA-14069 IA-14069 Phase 1 Clinical ILAb Co Ltd Arthritis, Rheumatoid Details
XTMAB-16 XTMAB-16 Phase 1 Clinical Xentria Inc Sarcoidosis Details
EYS-606 EYS-606 Phase 2 Clinical Eyevensys SAS Uveitis Details
Golimumab biosimilar( Alvotech) Phase 1 Clinical Alvotech Swiss Ag Details
Guselkumab/Golimumab JNJ-78934804 Phase 2 Clinical Janssen Research & Development Llc Colitis, Ulcerative; Crohn Disease Details
ND-009 ND-009 Phase 1 Clinical Numab Therapeutics Ag, Tillotts Pharma Ag Inflammation Details
Adalimumab biosimilar (Oncobiologics) ONS-3010 Phase 3 Clinical Outlook Therapeutics Inc Psoriasis Details

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