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IL-2

요약

Name:Interleukin-2
Target Synonym:T-cell growth factor,IL2,Interleukin 2,T Cell Growth Factor,Aldesleukin,IL-2,TCGF,Involved In Regulation Of T-Cell Clonal Expansion,Interleukin-2,Lymphokine
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:35
Lastest Research Phase:Approved

제품 리스트 구매

일부의 생물활성 데이터

GMP-L02H14-Cell-based assay
 IL-2 CELL

GMP Human IL-2 Protein (Cat. No. GMP-L02H14) stimulates proliferation of CTLL-2 cells. The specific activity of GMP Human IL-2 Protein is ≥ 1.20×10^7 IU/mg, which is calibrated against human Interleukin-2 China National Standard (NIFDC code: 270008) (QC tested). China National Institutes for Food and Drug Control (NIFDC) Standard was prepared and calibrated against human IL-2 WHO International Standard (NIBSC code: 86/500) by NIFDC.

IL2-H5215-Cell-based assay
 IL-2 CELL

Human IL-2 Protein, Tag Free (Cat. No. IL2-H5215) stimulates proliferation of CTLL-2 cells. The specific activity of Human IL-2 Protein, Tag Free is > 5.00×10^6 IU/mg, which is calibrated against Interleukin-2 (Human, rDNA derived) (2nd International Standard) (NIBSC code: 86/500) (QC tested).

IL2-C5249-SPR
 IL-2 SPR

Cynomolgus IL-2 R beta, His Tag (Cat. No. ILB-C52H9) immobilized on CM5 Chip can bind Cynomolgus IL-2, His Tag (Cat. No. IL2-C5249) with an affinity constant of 377 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL2-M52H3-SPR
 IL-2 SPR

Mouse IL-2, His Tag (Cat. No. IL2-M52H3) immobilized on CM5 Chip can bind Mouse IL-2 R beta, Fc Tag (Cat. No. ILB-M5253) with an affinity constant of 36.2 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

사용자 리뷰

Synonym Name

IL2,TCGF,lymphokine,Interleukin 2

Background

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Osteosarcoma; Leprosy, Lepromatous; Drug Resistant Epilepsy; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Waldenstrom Macroglobulinemia; Cholangitis, Sclerosing; HIV Wasting Syndrome; Arachnoiditis; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Pancreatitis, Chronic; Lymphoma, Follicular; Sarcoma; Xerostomia; Burning Mouth Syndrome; Neoplasm Metastasis; Mycobacterium avium-intracellulare Infection; Vascular Malformations; Amyotrophic Lateral Sclerosis; Melanoma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Erythema Nodosum; Anemia, Sideroblastic; Uterine Neoplasms; Lymphoma, Non-Hodgkin; Glioma; Angiodysplasia; Pelvic Pain; Appendiceal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Mycobacterium Infections; Gastric Antral Vascular Ectasia; Carcinoid Tumor; Lupus Erythematosus, Discoid; Stomatitis, Aphthous; Rhabdomyosarcoma; Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
T20K T-20K Phase 1 Clinical Cyxone Multiple Sclerosis Details
RG-6279 RG-6279 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours Details
S-95007 S-95007 Phase 2 Clinical Laboratoires Servier Immune System Diseases; Inflammation Details
SAR-444336 SAR-444336 Phase 1 Clinical Sanofi Inflammation Details
LMBP2-specific TCR-T cell therapy (TCRCure Biopharma) Phase 2 Clinical Tcrcure Biopharma Ltd Nasopharyngeal Carcinoma Details
SHR-1916 SHR-1916 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Solid tumours Details
STK-012 STK-012 Phase 1 Clinical Synthekine Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Microsatellite instability-high cancer; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Darleukin/fibromun L19-IL-2/ L19-TNF-α Phase 3 Clinical Philogen Spa Carcinoma, Merkel Cell; Carcinoma, Skin Appendage; Basal Cell Nevus Syndrome; Keratoacanthoma; Carcinoma, Squamous Cell; Lymphoma, T-Cell, Cutaneous; Melanoma; Sarcoma, Kaposi Details
ITI-1000 ITI-1000 Phase 2 Clinical Immunomic Therapeutics Inc Glioblastoma Details
NNC-0361-0041 NNC0361-0041; NNC-0361-0041 Phase 1 Clinical Novo Nordisk A/S Diabetes Mellitus, Type 1 Details
XTX-202 XTX-202 Phase 2 Clinical Solid tumours Details
Interleukin-2 gene therapy (St Jude Children's Research Hospital) Phase 1 Clinical St Jude Children's Research Hospital, National Cancer Institute Neuroblastoma Details
AU-007 BD-8; AU-007; BDG-8 Phase 2 Clinical Biolojic Design Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
PM-1016 PM1016; TILT-123 Phase 2 Clinical Tilt Biotherapeutics Ltd Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma Details
EQ101 EQ101 Phase 2 Clinical Equillium Inc Alopecia; Alopecia Areata Details
Bifikafusp alfa L19-IL-2 Phase 3 Clinical Philogen Spa Solid tumours; Carcinoma, Basal Cell; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Squamous Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
attIL2-T cell therapy Phase 1 Clinical MD Anderson Cancer Center Soft Tissue Neoplasms; Osteosarcoma; Sarcoma Details
Saltikva Phase 2 Clinical Salspera LLC Pancreatic Neoplasms Details
AVB-001 AVB-001 Phase 2 Clinical Avenge Bio Inc Ovarian Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details

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