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Frizzled-2

요약

Name:Frizzled-2
Target Synonym:Frizzled Class Receptor 2,Frizzled 2, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 2,FzE2,Fz-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

제품 리스트 구매

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제품번호 제품 설명 구조 순도 특징
FZ2-H5255 Human Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag
FZ2-H5255-structure
FZ2-H5255-sds
FZ2-H5251 Human Human Frizzled-2 / FZD2 Protein, Fc Tag
FZ2-H5251-structure
FZ2-H5251-sds

일부의 생물활성 데이터

FZ2-H5251-ELISA
 Frizzled-2 ELISA

Immobilized Human Frizzled-2, Fc Tag (Cat. No. FZ2-H5251) at 1 μg/mL (100 μL/well) can bind Wnt surrogate Human IgG1(D239E,L241M) | Human Lambda with a linear range of 0.1-8 ng/mL (QC tested).

FZ2-H5255-ELISA
 Frizzled-2 ELISA

Immobilized Human Frizzled-2, Fc Tag (Cat. No. FZ2-H5255) at 1 μg/mL (100 μL/well) can bind Wnt surrogate Human IgG1(D239E,L241M) | Human Lambda with a linear range of 0.1-8 ng/mL (QC tested).

Synonym Name

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

Background

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Clinical and Translational Updates

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