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FOLR1

요약

Name:Folate receptor alpha
Target Synonym:FRalpha,KB cells FBP,Adult folate-binding protein,Folate receptor 1,Folate receptor alpha,FR-alpha,FOLR1,Ovarian Tumor-Associated Antigen MOv18,Folate Receptor 1 (Adult),Folate Receptor, Adult,FOLR,FBP,Folate Binding Protein,FRα
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
FRα BsAb - 01 PCC Solid Tumor Ovarian cancer,Non-small cell lung cancer

라이센싱

Project Name Modality Therapeutic Area Indications Stage Right Available
FRα BsAb-ADC Bispecific antibody Oncology/Cancer Ovarian cancer Preclinical Global

제품 리스트 구매

일부의 생물활성 데이터

CHEK-ATP091-Cell-based assay
 FOLR1 FACS

Expression analysis of human FOLR1 on HEK293/Human FOLR1 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human FOLR1 Stable Cell Line or negative control cell using PE-labeled anti-human FOLR1 antibody.

FO1-HP2H9-Cell-based assay
 FOLR1 FACS

5e5 of anti-FOLR1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human FOLR1, His Tag (Cat. No. FO1-HP2H9) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

FO1-H82E2-SPR
 FOLR1 SPR

Biotinylated Human FOLR1, His,Avitag (Cat. No. FO1-H82E2) immobilized on SA Chip can bind Folic acid-BSA with an affinity constant of 83.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

FO1-C82E8-ELISA
 FOLR1 ELISA

Immobilized Folic acid-BSA conjugate at 5 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus / Rhesus macaque FOLR1 Protein, His,Avitag (Cat. No. FO1-C82E8) with a linear range of 0.06-1 ng/mL (QC tested).

사용자 리뷰

Synonym Name

FOLR-1,FBP,FOLR

Background

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Folinic Acid FTHF Approved Anemia; Autism Spectrum Disorder; Down Syndrome; Rectal Neoplasms; Diarrhea; Vitamin B 12 Deficiency; Colorectal Neoplasms Details
Pafolacianine Sodium Pteroyl-L-Tyr-S0456; OTL-38; EC-17; OTL-0038 Approved On Target Laboratories Inc Cytalux United States Ovarian Neoplasms On Target Laboratories Inc 2021-11-29 Ovarian Neoplasms; Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Neoplasms; Breast Neoplasms; Pituitary Neoplasms; Lung Neoplasms Details
Mirvetuximab soravtansine M9346-Asulfo-SPDB-DM4; IMGN-853 Approved Immunogen Inc United States Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms Immunogen Inc 2022-11-14 Ovarian Neoplasms; Solid tumours; Cystadenoma, Serous; Carcinoma, Ovarian Epithelial; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Endometrial Neoplasms; Uterine Neoplasms; Carcinosarcoma; Adenocarcinoma Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Noscapine-folate conjugate Phase 1 Clinical Emory University Hematologic Neoplasms; Inflammation Details
4S-CAR-FRa 4S-CAR-FRa Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Carcinoma, Transitional Cell; Urinary Bladder Neoplasms Details
MOv19-BBz CAR-T cells Therapy University Of Pennsylvania Details
Epofolate BMS-753493 Bristol-Myers Squibb Company, Novartis Pharma Ag Details
BAT-8006 BAT8006; BAT-8006 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Neoplasms Details
ITIL-306 ITIL-306 Phase 1 Clinical Instil Bio Inc Solid tumours; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Genital Neoplasms, Female; Carcinoma, Non-Small-Cell Lung Details
ELU-001 ELU-001 Phase 2 Clinical Elucida Oncology Inc Cholangiocarcinoma; Neoplasm Metastasis; Carcinoma, Endometrioid; Adenocarcinoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Bile Duct Neoplasms; Peritoneal Neoplasms; Breast Neoplasms; Biliary Tract Neoplasms; Klatskin Tumor; Colonic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Ovarian Epithelial; Ovarian Diseases; Stomach Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Uterine Diseases Details
PRO-1184 PRO-1184 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Mesothelioma; Breast Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Farletuzumab ecteribulin MORAb-202 Phase 2 Clinical Eisai Co Ltd, Morphotek Inc, Bristol-Myers Squibb Company Ovarian Neoplasms; Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Luveltamab tazevibulin SP-7219; DBCO-Alexa647-conjugated SP7219; STRO-002; SP-7675; SP-7676 Phase 1 Clinical Sutro Biopharma Inc Ovarian Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Endometrioid Details
MOv-18 IgE MOv-18 IgE; MOv18; MOv-18 Phase 1 Clinical King'S College London, Cancer Research UK Ovarian Neoplasms; Neoplasms Details
Arfolitixorin ISO-901; 6R-MTHF Phase 3 Clinical Isofol Medical Ab Rectal Neoplasms; Colonic Neoplasms; Osteosarcoma; Colorectal Neoplasms Details
CBP-1008 CBP-1008 Phase 2 Clinical Coherent Biopharma Suzhou Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell Details

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