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FGF-4

요약

Name:Fibroblast growth factor 4
Target Synonym:Fibroblast Growth Factor 4 Splice Isoform,Oncogene HST,K-FGF,KFGF,KS3,HBGF-4,Heparin-binding growth factor 4,HST,HSTF1,Fibroblast growth factor 4,FGF4,FGF-4,Transforming Protein KS3,Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene,Heparin Secretory Transforming Protein 1,Kaposi Sarcoma Oncogene,HSTF-1,HST-1,Heparin Secretory-Transforming Protein 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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제품번호 제품 설명 구조 순도 특징
FG4-H51H3 Human Human FGF-4 Protein, His Tag
FG4-H51H3-structure
FG4-H51H3-sds

일부의 생물활성 데이터

FG4-H51H3-SPR
 FGF-4 SPR

Human FGF R4, Fc Tag (Cat. No. FG4-H5253) immobilized on CM5 Chip can bind Human FGF-4 Protein, His Tag (Cat. No. FG4-H51H3) with an affinity constant of 1.48 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

FG4-H51H3-ELISA
 FGF-4 ELISA

Immobilized Human FGF-4 Protein, His Tag (Cat. No. FG4-H51H3) at 5 μg/mL (100 μL/well) can bind Human FGF R3 (IIIb), Fc Tag (Cat. No. FGB-H5259) with a linear range of 1-39 ng/mL (QC tested).

Synonym Name

FGF-4, Fibroblast growth factor 4, HST, HST-1

Background

Fibroblast growth factor-4 (FGF4) is expressed in embryonic stages and in adult tissues, where it plays critical roles in modulating multiple cellular functions. Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers. In lung adenocarcinoma (ADC) cell lines, FGF4 could alter cell morphology, promote epithelial-mesenchymal transition-associated protein expression, and enhance cell proliferation, migration/invasion and colony initiation. In B-cell lymphoma, FGF4 secretion by cancer cells induces Jag1 expression in neighbor Endothelial cell that in turn activates Notch2 in lymphoma cells.

Clinical and Translational Updates

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