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CD69

요약

Name:DNA (cytosine-5)-methyltransferase 1
Target Synonym:Dnmt1,AIM,MCMT,DNA methyltransferase HsaI,DNA Methyltransferase 1,CXXC-Type Zinc Finger Protein 9,DNA MTase HsaI,M.HsaI,CXXC9,EC:2.1.1.37,DNA (Cytosine-5-)-Methyltransferase 1,DNMT,DNA (Cytosine-5)-Methyltransferase 1,EC 2.1.1.37,ADCADN,HSN1E
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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CD9-H5222 Human Human CD69 / CLEC2C Protein, His Tag
CD9-H5222-structure
CD9-H5222-sds

Synonym Name

CD69,CLEC2C,AIM,BL-AC/P26,EA1,GP32/28,MLR-3

Background

Early activation antigen CD69 is also known as C-type lectin domain family 2 member C (CLEC2C), Activation inducer molecule (AIM), Early T-cell activation antigen p60, Leukocyte surface antigen Leu-23. CD69 contains one C-type lectin domain. CD69 / CLEC2C is expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. CD69 is induced by antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes and by interaction of IL-2 with the p75 IL-2R on the surface of NK cells. CD69 / CLEC2C involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Triclabendazole EGA-230B; CGA-89317; NVP-EGA230 Approved Novartis Pharma Ag Egaten, Fasinex, Triclathera United States Fascioliasis Novartis Pharma Ag 1989-01-01 Fascioliasis Details
Decitabine/Cedazuridine ASTX-727; E-7727/decitabine; Decitabine/E7727 Approved Astex Pharmaceuticals Inc Inqovi United States Myelodysplastic Syndromes Otsuka Pharmaceutical Co Ltd 2020-07-07 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Solid tumours; Leukemia; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Acute; Glioma; Nervous System Neoplasms; Neurilemmoma Details
Mecobalamin E-0302 Approved Myelogen, Naso B12, NASOCOBAL, Methycobal, 弥尔神, 悦敏兴, RHINOCOBAL, 奇信, 曲力, 弥可保 Peripheral Nervous System Diseases; Autistic Disorder; Neuralgia; Neuritis; Vitamin B 12 Deficiency; Amyotrophic Lateral Sclerosis; Fibromyalgia Details
Decitabine DAC; AzadC; E-7373; 5-aza-CdR; NSC-127716 Approved Eisai Co Ltd 达珂, Dacogen EU Leukemia, Myeloid, Acute Janssen-Cilag International Nv 2006-05-02 Burkitt Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Breast Neoplasms; Neuroblastoma; Primary Myelofibrosis; Colorectal Neoplasms; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Lymphoma; Urinary Bladder Neoplasms; Lung Neoplasms; Thyroid Neoplasms; Precancerous Conditions; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Metastasis; Thyroid Cancer, Papillary; Breast Neoplasms, Male; Melanoma; Anemia, Sickle Cell; Lymphoma, Large B-Cell, Diffuse; Solid tumours; Leukemia; Purpura, Thrombocytopenic, Idiopathic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia, Promyelocytic, Acute; Esophageal Neoplasms; Thalassemia; Neutropenia; Myelodysplastic Syndromes; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large-Cell, Immunoblastic; Plasmacytoma; Small Cell Lung Carc Details
Azacitidine NSC-102816; 5-aza-CR; CC-486; NS-17; U-18496; NEX-18; NEX-18a Approved Celgene Corp 维达莎, Vidaza, Onureg United States Leukemia, Myeloid, Acute Celgene Corp 2004-05-19 Leukemia, Myeloid, Acute; Immune System Diseases; Prostatic Neoplasms; Tuberculosis, Pulmonary; Breast Neoplasms; Osteosarcoma; Sarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Brain Neoplasms; Primary Myelofibrosis; Hepatic Insufficiency; Multiple Myeloma; Lymphoma; Lung Neoplasms; Leukemia, Myelomonocytic, Juvenile; Thyroid Neoplasms; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung; Myelodysplastic-Myeloproliferative Diseases; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Large Granular Lymphocytic; Myelodysplastic Syndromes; Head and Neck Neoplasms; Intestinal Neoplasms; Solid tumours; Hematologic Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Ependymoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Leukemia, Myelomonocytic, Chronic; Leukemia; beta-Thalassemia; Lymphoma, Large B-Cell, Diffuse; Plasmacytoma; Myeloproliferative Disorders; Neoplasms; Nasopharyngeal Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Hodgkin Disea Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
FdCyd NSC-48006; Ro-5-1090 Phase 2 Clinical City Of Hope National Medical Center, National Cancer Institute Head and Neck Neoplasms; Esophageal Neoplasms; Neoplasms; Myelodysplastic Syndromes; Urinary Bladder Neoplasms; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Azacitidine/Cedazuridine ASTX-030 Phase 3 Clinical Otsuka Pharmaceutical Co Ltd Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Decitabine/Tetrahydrouridine EPI-01 Phase 2 Clinical Epicdestiny Anemia, Sickle Cell Details
Curcumin VOLT-03; VOLT-3; NSC-32982 Phase 3 Clinical University Of Pennsylvania Renal Insufficiency, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Breast Neoplasms; Oral Submucous Fibrosis; Tobacco Use Disorder; Cardiovascular Diseases; Cognitive Dysfunction; Neuralgia; Colorectal Neoplasms; Cervical Intraepithelial Neoplasia; Uterine Cervical Dysplasia; Cigarette Smoking; Asthma; Chronic Periodontitis; Lung Neoplasms; Lichen Planus, Oral; Adenocarcinoma, Mucinous; Inflammation; Osteoarthritis; Uterine Cervical Neoplasms; Aortic Aneurysm, Abdominal; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Adenocarcinoma; Neoplasm Metastasis; Macular Degeneration; Neoplasms; Drug-Related Side Effects and Adverse Reactions; Adenomatous Polyposis Coli; Optic Atrophy, Hereditary, Leber; Digestive System Diseases; Depression; Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2; Gastritis, Atrophic; Radiodermatitis; Pain; Spasm; Rectal Neoplasms; Atherosclerosis; Primary Dysautonomias; Arthritis, Rheumatoid; Spondylitis, An Details
Guadecitabine Sodium SGI-110; S-110; 0RB89YH367 (UNII code) Phase 2 Clinical Otsuka Holdings Co Ltd Klatskin Tumor; Adenocarcinoma; Paraganglioma; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Gallbladder Neoplasms; Fallopian Tube Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Peritoneal Neoplasms; Cholangiocarcinoma; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Myeloproliferative Disorders; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Stomach Neoplasms; Carcinoma, Renal Cell; Pheochromocytoma; Kidney Neoplasms; Chondrosarcoma Details
EF-009 EF-009 Phase 2 Clinical Everfront Biotech Co Ltd Pancreatic Neoplasms Details
NTX-301 NTX-303 Phase 2 Clinical Southern Research Institute, Pinotbio Inc Solid tumours; Neoplasms Details

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