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Your Position: > Protein > GAS6 > GA6-H5246

Human GAS6 (49-678) Protein, His Tag

  • Synonym
    GAS6,GAS-6,AXLLG
  • Source
    Human GAS6 Protein, His Tag(GA6-H5246) is expressed from human 293 cells (HEK293). It contains AA Ala 49 - Ala 678 (Accession # Q14393-2).
  • Molecular Characterization
    GAS6 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 71.8 kDa. The protein migrates as 80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
GAS6 SDS-PAGE

Human GAS6 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 GAS6 ELISA

Immobilized Human GAS6 Protein, His Tag (Cat. No. GA6-H5246) at 5 μg/mL (100 μL/well) can bind Human Axl, Fc Tag (Cat. No. AXL-H5253) with a linear range of 0.06-1 ng/mL (QC tested).

 GAS6 ELISA

Immobilized Human GAS6 Protein, His Tag (Cat. No. GA6-H5246) at 10 μg/mL (100 μL/well) can bind Human TYRO3, Fc Tag (Cat. No. TY3-H5251) with a linear range of 2-20 ng/mL (Routinely tested).

 GAS6 ELISA

Immobilized Human GAS6 Protein, His Tag (Cat. No. GA6-H5246) at 10 μg/mL (100 μL/well) can bind Human MERTK, Fc Tag (Cat. No. MEK-H5253) with a linear range of 0.04-1.3 μg/mL (Routinely tested).

Bioactivity-SPR
 GAS6 SPR

Human Axl, Fc Tag (Cat. No. AXL-H5253) captured on Protein A Chip can bind Human GAS6 Protein, His Tag (Cat. No. GA6-H5246) with an affinity constant of 38.6 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
  • Clinical and Translational Updates

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