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Your Position: > Antibody > DM-1 > DM1-PLY73

HRP conjugated Monoclonal Anti-DM-1&DM-4 Antibody,Mouse IgG1

  • Source

    HRP conjugated Monoclonal Anti-DM-1&DM-4 Antibody,Mouse IgG1 is a Mouse monoclonal antibody produced from a hybridoma created by fusing SP2/0 myeloma and Mouse B-lymphocytes.

  • Species

    Mouse

  • Isotype

    Mouse IgG1 | Mouse Kappa

  • Conjugate

    HRP-Conjugated

  • Antibody Type

    Hybridoma Monoclonal

  • Reactivity

    Chemical

  • Immunogen

    DM-1.

  • Specificity

    This product is a specific antibody specifically reacts with DM-1 and DM-4.

  • Application
    ApplicationRecommended Usage
    ELISA1-500 ng/mL
  • Purity

    >90% as determined by SDS-PAGE.

  • Purification

    Protein A purified/ Protein G purified

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
DM-1 SDS-PAGE

HRP conjugated Monoclonal Anti-DM-1&DM-4 Antibody,Mouse IgG1 on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 DM-1 ELISA

Immobilized Trastuzumab-DM1 (T-DM1) at 2 μg/mL (100 μL/well) can bind HRP conjugated Monoclonal Anti-DM-1&DM-4 Antibody,Mouse IgG1 (Cat. No. DM1-PLY73) with a linear range of 0.24-15.63 ng/mL (QC tested).

  • Background
    Mertansine (DM-1) is a tubulin inhibitor that binds to the ends of microtubules and inhibits microtubule dynamics. DM-1(Mertansine) has antitumor activity and functions as a regulator of tubulin. It is an alpha-amino acid ester, a carbamate, an epoxide, an organic heterocyclic tetracyclic compound, an organochlorine compound, a mercaptan, and a maydenin alkaloid. DM-1, derived from Mydenin, is a cytotoxic component of antibody-drug conjugations that produce antibody-drug conjugations via a sulfhydryl group splice with SPP (n-succinimide 4- (2-pyridyl dithio)) or SMCC (4- (3-mercapto-2, 5-dioxy-1 pyrrolidyl) -cyclohexanic acid) splice.
  • Clinical and Translational Updates

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재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 525,000

가격(KRW) : 2,070,000

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약물 개발 현황

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:2 Details
  • Latest Research Phase:Phase 2 Clinical

Datasheet & Documentation

DMF 신청
DMF (Drug Master File)

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