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Your Position: > Protein > LRP-1 > LR1-H5254

Human LRP-1 / cluster Ⅱ Protein, Fc Tag (MALS verified)

  • Synonym
    A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5
  • Source
    Human cluster Ⅱ Protein, Fc Tag(LR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Arg 786 - Leu 1165 (Accession # Q07954-1).
    Predicted N-terminus: Arg 786
  • Molecular Characterization
    LRP-1 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 68.0kDa. The protein migrates as 75-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.1 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
LRP-1 SDS-PAGE

Human cluster Ⅱ Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
LRP-1 MALS images

The purity of Human cluster Ⅱ Protein, Fc Tag (Cat. No. LR1-H5254) is more than 90% and the molecular weight of this protein is around 165-195 kDa verified by SEC-MALS.

Bioactivity-BLI
 LRP-1 BLI

Loaded Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) on NTA Biosensor, can bind Human cluster Ⅱ Protein, Fc Tag (Cat. No. LR1-H5254) with an affinity constant of 7.58 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

  • Background
    Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.
  • Clinical and Translational Updates

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재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 600,000

가격(KRW) : 4,200,000

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약물 개발 현황

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  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Preclinical

Datasheet & Documentation

DMF 신청
DMF (Drug Master File)

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