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Your Position: > Protein > SHP-2 > SH2-H5248

Human SHP-2 Protein, His Tag

  • Synonym
    SHP-2
  • Source
    Human SHP-2, His Tag(SH2-H5248) is expressed from E. coli cells. It contains AA Thr 2 - Arg 593 (Accession # Q06124-2).
    Predicted N-terminus: His
  • Molecular Characterization
    SHP-2 Structure

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 69.7 kDa. The protein migrates as 65-66 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
SHP-2 SDS-PAGE

Human SHP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity

Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site. The specific activity is >3 umol/min/mg, measured under the described conditions (QC tested).

 SHP-2 ENZYME

Serial dilutions of SHP394 (an orally efficacious inhibitor of protein tyrosine phosphatase SHP2) were added into Human SHP-2 Protein, His Tag(SH2-H5248) enzymatic reactions. The half maximal inhibitory concentration (IC50) is 19.36 nM (Routinely tested).

  • Background
    SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. SHP-2 takes key role in transducing signal relay from the cell surface to the nucleus, and is a important intracellular regulator in mediating cell proliferation and differentiation.
  • Clinical and Translational Updates

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