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CTXB

요약

Name:Toxin B
Target Synonym:EC:3.4.22.-,Toxin B,toxB
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Synonym Name

CTXB,TOXB

Background

Cholera enterotoxin subunit B (CTXB) is also known as cholera enterotoxin B chain, cholera enterotoxin gamma chain and choleragenoid. Vibrio cholerae O1 exists as two major serotypes, Inaba and Ogawa, which are associated with the O antigen of the lipopolysaccharide and are capable of unequal reciprocal interconversion. The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. CTXB can bind five GM1 gangliosides. Also, it has no toxic activity by itself.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Bezlotoxumab CDB-1; MK-6072; MBL-CDB1; MDX-1388 Approved Merck Sharp & Dohme Corp Zinplava Japan Clostridium Infections; Diarrhea Merck Sharp & Dohme Corp 2016-10-21 Multiple Organ Failure; Inflammatory Bowel Diseases; Death; Clostridium Infections; Diarrhea Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
IMM-529 IMM-529 Immuron Details
Ribaxamase SYN-004(Synthetic Biologics) Phase 2 Clinical Graft vs Host Disease Details
LMN-201 LMN-201 Phase 3 Clinical Lumen Bioscience Inc Clostridium Infections Details

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