Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
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Synonym Name
TLR4/hToll/CD284/Toll-like receptor 4
Background
Toll-like receptor 4 (TLR4) is a member of the toll-like receptor (TLR) family and highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs). TLR4 is expressed on the cell surface on both hematopoietic and nonhematopoietic cells, including endothelial cells], cardiac myocytes, and cells of the central nervous system (CNS). TLR4 has been regarded as the sensing receptor for gram-negative lipopolysaccharide (LPS). Further research indicated that TLR4also binds endogenous molecules produced as a result of tissue injury. Thus, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response.
Clinical and Translational Updates
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