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MAdCAM-1

요약

Name:Mucosal addressin cell adhesion molecule-1
Target Synonym:Mucosal addressin cell adhesion molecule 1,MADCAM1,hMAdCAM-1,Mucosal Vascular Addressin Cell Adhesion Molecule 1,MACAM1,MAdCAM-1,Mucosal Addressin Cell Adhesion Molecule-1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

제품 리스트 구매

일부의 생물활성 데이터

MAM-H52H4-SPR
 MAdCAM-1 SPR

Human MAdCAM-1, His Tag (Cat. No. MAM-H52H4) immobilized on CM5 Chip can bind Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) with an affinity constant of 0.227 μM as determined in a SPR assay (Biacore 8K) (QC tested).

MAM-H5253-ELISA
 MAdCAM-1 ELISA

Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 2 μg/mL (100 μL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 0.05-1 ng/mL (QC tested).

Synonym Name

MAdCAM-1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

Background

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Vedolizumab MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02 Approved Millennium Pharmaceuticals Inc 安吉优, Entyvio EU Pouchitis Takeda Pharma A/S 2014-05-20 HIV Infections; Acquired Immunodeficiency Syndrome; Solid tumours; Inflammatory Bowel Diseases; Pediatric Crohn's disease; Pouchitis; Colitis; Celiac Disease; Cholangitis, Sclerosing; Pediatric ulcerative colitis; Colitis, Ulcerative; Urogenital Neoplasms; Crohn Disease; Melanoma; Carcinoma, Non-Small-Cell Lung Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Ontamalimab SHP-647; PF-00547659; PF-547659 Pfizer Inc Details

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