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Prolactin R

요약

Name:Prolactin receptor
Target Synonym:PRL-R,PRLR,Prolactin Receptor,Secreted Prolactin Binding Protein,HPRL Receptor,RI-PRLR,HPRLrI,HPRL,MFAB,Receptors, Prolactin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

제품 리스트 구매

제품 상태별:
제품 유형별 :
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태그별:
결합물별:
제품번호 제품 설명 구조 순도 특징
PRR-H52Ha Human Human Prolactin R / PRLR Protein, His Tag
PRR-H52Ha-structure
PRR-H52Ha-sds
PRP-H5251 Human Human Prolactin R / PRLR Protein, Fc Tag
PRP-H5251-structure
PRP-H5251-sds

일부의 생물활성 데이터

PRP-H5251-ELISA
 Prolactin R ELISA

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. PRN-H5257) at 1 μg/mL (100 μL/well) can bind Human Prolactin R Protein, Fc Tag (Cat. No. PRP-H5251) with a linear range of 2-78 ng/mL (QC tested).

PRR-H52Ha-ELISA
 Prolactin R ELISA

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. PRN-H5257) at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. PRR-H52Ha) with a linear range of 20-156 ng/mL (QC tested).

Synonym Name

Prolactin R, PRLR, PRL-R

Background

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
BAY-1158061 BAY-1158061; HMI-115 Phase 2 Clinical Bayer AG Alopecia; Pain; Endometriosis Details

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