Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
Human Activin RIIA Protein, His Tag (Cat. No. ACA-H5243) immobilized on CM5 Chip can bind Human Activin A Protein, premium grade (Cat. No. ACA-H5314) with an affinity constant of 85.9 pM as determined in a SPR assay (Biacore 8K) (QC tested).
Mouse Activin RIIA Protein, His Tag (Cat. No. ACA-M52H3) capture on NTA-Series S sensor chip can bind Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) with an affinity constant of 83.8 pM as determined in a SPR assay (Biacore 8K) (QC tested).
Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.