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Your Position: > LIF R

LIF R

요약

Name:Leukemia inhibitory factor receptor
Target Synonym:LIF receptor,LIF-R,CD118
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

제품 리스트 구매

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제품번호 제품 설명 구조 순도 특징
LIR-H4252 Human Human LIF R / CD118 Protein, Fc Tag
LIR-H4252-structure
LIR-H4252-sds

일부의 생물활성 데이터

LIR-H4252-MALS-HPLC
 LIF R ELISA

Immobilized ActiveMax® Human LIF, Tag Free (Cat. No. LIF-H521b) at 0.2 μg/mL (100 μL/well) can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 4-125 ng/mL (QC tested).

Synonym Name

LIFR,CD118,FLJ98106,FLJ99923,SJS2,STWS,SWS

Background

Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

Clinical and Translational Updates

Related Molecule

LIF

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