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Your Position: 홈 > Cell Grade Beads > BCMA > MBS-C004

ActiveMax® Human BCMA μBeads, premium grade (for cells) DMF

The Magnetic Stand (Cat.No. MB-01 & Cat.No. MB-02) can be used in conjunction with Beads.
ProductSizeAmount
ActiveMax® Human BCMA μBeads, premium grade (for cells)2.5 mg2.5×10⁷ beads
ActiveMax® Human BCMA μBeads, premium grade (for cells)10 mg (2.5 mg×4)1.0×10⁸ beads
  • Product Description
    ActiveMax® Human BCMA μBeads, premium grade (for cells) are uniform, superparamagnetic beads of 5.5 µm in diameter immobilized with Human BCMA protein expressed from human 293 cells (HEK293) and contains AA Met 1 - Ala 54 (Accession # Q02223-1).
    ActiveMax® Human BCMA μBeads, premium grade (for cells) are produced under sterile manufacturing conditions (ISO 5), and no animal- or human-derived components are used throughout the production process. It is produced under our rigorous quality control system that includes a comprehensive set of tests including sterility and endotoxin tests.
  • Application
    ActiveMax® Human BCMA μBeads, premium grade (for cells) are designed to stimulate in vitro BCMA-specific CAR-T cells or UCAR-T cells, similar to the tumor cell lines that express human BCMA antigen. It can be used as follows:
    Evaluating the characteristics of CAR-T cells or UCAR-T cells.
    In vitro expansion of BCMA-specific CAR-T cells or UCAR-T cells.
    In vitro enrichment of BCMA-specific CAR-T cells or UCAR-T cells.
  • Reconstitution

    See Certificate of Analysis (CoA) for detailed instruction.

  • Storage
    This product is stable in storage under the following conditions: -20˚C for 12 months in lyophilized state. -70°C for 3 months under sterile conditions after reconstitution.Please avoid repeated freeze-thaw cycles after reconstitution. Immediate use after reconstitution is highly recommended.
  • Sterility
    Negative
  • Endotoxin
    Less than 0.002 EU per μg by the LAL method / rFC method.
  • Important Note
    This product is for research use only and not intended for therapeutic or in vivo diagnostic use.
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

FACS Data
BCMA FACS

Assay of human BCMA protein on the μBeads surface by Flow cytomtry. The human BCMA conjugated on the μBeads (Cat. No. MBS-C004) surface were fluorescently stained using PE labeled anti-human BCMA antibody and analyzed by flow cytometry.

Protocol
Application Data
BCMA APPLICATION DATA

BCMA CAR-T cells were stimulated with ActiveMax® Human BCMA μBeads (MBS-C004) for 24 h , and cell-free supernatants were harvested for evaluating IFN-γ、TNF-α、IL-4、IL-6 secretion by flow cytomtry. The results showed that BCMA CAR-T cells released significantly larger amounts of IFN-γ、TNF-α、IL-4、IL-6 into the supernatants in response to BCMA μBeads.

BCMA APPLICATION DATA

BCMA CAR-T cells were stimulated with ActiveMax® Human BCMA μBeads (MBS-C004) for 24h, and cell-free supernatants were harvested for evaluating Granzyme B, Perforin secretion by ELISA. The results showed that BCMA CAR-T cells released significantly larger amounts of Granzyme B, Perforin into the supernatants in response to BCMA μBeads.

BCMA APPLICATION DATA

ActiveMax® Human BCMA μBeads, premium grade (for cells)(Cat.No.MBS-C004) can activate BCMA-specific CAR-T cells by detecting the secretion of IFN- γ in vitro.

  • Clinical and Translational Updates

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재고상품 출발날짜: 영업일 기준 4일

가격(USD) : 2390.00

가격(USD) : 5875.00

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